Olli T. Raitakari, MD, PhD; Mark R. Adams, MB, BS, PhD, FRACP; Robyn J. McCredie, BSc; Kaye A. Griffiths, DMU; David S. Celermajer, MB, BS, PhD, FRACP
Raitakari OT, Adams MR, McCredie RJ, Griffiths KA, Celermajer DS. Arterial Endothelial Dysfunction Related to Passive Smoking Is Potentially Reversible in Healthy Young Adults. Ann Intern Med. 1999;130:578-581. doi: 10.7326/0003-4819-130-7-199904060-00017
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Published: Ann Intern Med. 1999;130(7):578-581.
Passive smoking is associated with early arterial damage, but the potential for reversibility of this damage is unknown.
To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis.
Academic medical center.
60 healthy persons 15 to 39 years of age: 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to environmental tobacco smoke for ≥ 1 hour per day for ≥ 2 years), and 20 former passive smokers.
Arterial endothelial function measured by noninvasive ultrasonography.
Endothelium-dependent dilatation was significantly better in former passive smokers (5.1% ± 4.1% [range, −1.2% to 15.6%]) than in current passive smokers (2.3% ± 2.1% [range, −0.2% to 6.7%]) (P = 0.01), although both groups were significantly impaired compared with nonsmoking controls (8.9% ± 3.2% [range, 2.1% to 16.7%]) (P ≤ 0.01 for both comparisons).
In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.
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Cardiology, Coronary Risk Factors, Smoking.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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