John S. Adams, MD; Cindy F. Song, BS; Vitaly Kantorovich, MD
Adams JS, Song CF, Kantorovich V. Rapid Recovery of Bone Mass in Hypercalciuric, Osteoporotic Men Treated with Hydrochlorothiazide. Ann Intern Med. 1999;130:658-660. doi: 10.7326/0003-4819-130-8-199904200-00012
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Published: Ann Intern Med. 1999;130(8):658-660.
Chronic hypercalciuria can contribute to osteoporosis, particularly in men.
To ascertain the effects of resolution of hypercalciuria on bone mineral density.
Referral service for metabolic bone disease in a tertiary-care teaching hospital.
Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.
Hydrochlorothiazide, 25 mg twice daily, for a mean (± SD) of 7.8 ± 3.6 months.
Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.
Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.
Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.
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Endocrine and Metabolism, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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