Kavita Goel, MD; Dhananjai Menzies, MD; Burke A. Cunha, MD
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Goel K., Menzies D., Cunha B.; Elevated International Normalized Ratio Associated with Trovafloxacin. Ann Intern Med. 1999;131:72. doi: 10.7326/0003-4819-131-1-199907060-00024
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Published: Ann Intern Med. 1999;131(1):72.
TO THE EDITOR:
The international normalized ratio (INR [normal ≤ 1.0]) may become elevated in patients receiving trovafloxacin. We report four cases of elevated INR related to trovafloxacin.
Case 1: A 69-year-old woman was admitted with recurrent nephrolithiasis. At admission, her INR was normal. She was treated with cefepime for presumed pneumonia, but her condition worsened. Cefepime therapy was discontinued, and intravenous trovafloxacin therapy, 200 mg every 24 hours, was started. After 3 days of trovafloxacin treatment, her INR markedly increased to 5.26. Trovafloxacin therapy was discontinued, and her INR returned to normal in 3 days.
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