Brian L. Strom, MD, MPH; Judith L. Kinman, MA; Elias Abrutyn, MD
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Strom B., Kinman J., Abrutyn E.; Risk Factors for Infective Endocarditis. Ann Intern Med. 1999;131:155. doi: 10.7326/0003-4819-131-2-199907200-00019
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Published: Ann Intern Med. 1999;131(2):155.
In response to Dr. Jacobson's letter, although 27 participants did receive antibiotic prophylaxis, they constituted only 21% of the 127 participants who had dental treatment in the 3-month period. More important, among those with indications for antibiotics (that is, patients with previously known cardiac valve abnormalities undergoing dental work), only 17 of 29 (59%) case-patients with dental treatment received antibiotic prophylaxis, compared with 3 (50%) of 6 controls (P = 1.0). In fact, the unadjusted odds ratio for the association between dental therapy and infective endocarditis was 0.5 (95% CI, 0.01 to 9.6) among those with antibiotic prophylaxis, compared with 0.3 (CI, 0.01 to 4.2) among those without antibiotic prophylaxis. Thus, not only were our results not due to widespread use of prophylaxis, but they also did not suggest a protective effect.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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