Teresa A. Brentnall, MD; Mary P. Bronner, MD; David R. Byrd, MD; Rodger C. Haggitt, MD; Michael B. Kimmey, MD
Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB. Early Diagnosis and Treatment of Pancreatic Dysplasia in Patients with a Family History of Pancreatic Cancer. Ann Intern Med. 1999;131:247-255. doi: 10.7326/0003-4819-131-4-199908170-00003
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Published: Ann Intern Med. 1999;131(4):247-255.
Pancreatic cancer is the fourth leading cause of cancer death in the United States, and its incidence is increasing. At the time of diagnosis, 96% to 99% of patients are incurable and have a median survival of less than 1 year (1-3). Hereditary predisposition accounts for at least 10% of cases of pancreatic cancer (4). Some inherited syndromes that confer a high risk for pancreatic cancer include familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, cystic fibrosis, and hereditary pancreatitis. However, patients who inherit pancreatic cancer in an autosomal dominant fashion (familial pancreatic cancer) are at the highest risk, which can approach 50% (4, 5).
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Gastroenterology/Hepatology, Pancreatic Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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