Sybil A. Tasker, MD; John J. Treanor, MD; William B. Paxton, MD, PhD; Mark R. Wallace, MD
Tasker SA, Treanor JJ, Paxton WB, Wallace MR. Efficacy of Influenza Vaccination in HIV-Infected Persons: A Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 1999;131:430-433. doi: 10.7326/0003-4819-131-6-199909210-00006
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Published: Ann Intern Med. 1999;131(6):430-433.
Although influenza vaccination is recommended in persons infected with HIV-1, its efficacy is unknown.
To assess the immunogenicity, efficacy, and risks associated with influenza vaccination in persons infected with HIV-1.
Randomized, double-blind, placebo-controlled trial.
Outpatient military clinic.
102 patients with HIV-1 infection.
Influenza vaccine (nÂ =Â 55) or saline placebo (nÂ =Â 47).
Influenza antibody titers, CD4+ cell counts, and plasma HIV-1 RNA levels at baseline, 1 month after immunization, and 3 months after immunization; viral cultures from persons presenting with respiratory illness; and respiratory symptom interview.
Twenty-three placebo recipients (49%) and 16 vaccine recipients (29%) reported respiratory symptoms (PÂ =Â 0.04). Ten placebo recipients but no vaccine recipients had laboratory-confirmed symptomatic influenza (PÂ <Â 0.001) (protective efficacy, 100% [95% CI, 73% to 100%]). No effect on plasma HIV-1 RNA levels or CD4+ cell counts was noted.
Influenza vaccination is highly effective in HIV-1-infected persons and does not seem to be associated with substantial changes in viral load or CD4 cell count.
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Infectious Disease, Vaccines/Immunization, Influenza, Prevention/Screening.
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