Philip Goldwasser, MD
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Goldwasser P. Prediction Equation for Glomerular Filtration Rate. Ann Intern Med. 1999;131:629. doi: 10.7326/0003-4819-131-8-199910190-00017
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Published: Ann Intern Med. 1999;131(8):629.
TO THE EDITOR:
In supplying a rationale for the inclusion of race as a factor in a new predictive equation for GFR, Levey and colleagues (1) cite only their unpublished observation that black ethnicity is associated with a higher creatinine excretion rate. In fact, this finding was previously reported in both healthy persons and patients with renal disease, as was a predictive equation that adjusts for race and age (2-4).
The loss of muscle mass is a well-known consequence of uremia. Because the difference in creatinine excretion between black and white persons may widen with progressive renal insufficiency (2-4), it would be of interest for Levey and colleagues to use their database to examine the hypothesis that the decrease in creatinine excretion with declining GFR occurs at a slower rate in black persons than in white persons.
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