Johan R.M. Cruysberg, MD, PhD
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Cruysberg J.; Ocular Venous Occlusion and Hyperhomocysteinemia. Ann Intern Med. 1999;131:632-633. doi: 10.7326/0003-4819-131-8-199910190-00028
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Published: Ann Intern Med. 1999;131(8):632-633.
TO THE EDITOR:
de Bruijne and colleagues (1) suggested an association between venous occlusion in the eye and elevated total plasma homocysteine levels. This association was established in an earlier study published in 1993 (2). In 19 patients who had retinal vein occlusion or retinal artery occlusion before 50 years of age, the incidence of hyperhomocysteinemia, as observed in heterozygosity for homocystinuria, was studied by the performance of a standardized, oral methionine-loading test. In 4 of the 19 patients (21%), 2 with retinal artery occlusion and 2 with central retinal vein occlusion, the afterload peak levels of homocysteine exceeded the mean level (established in normal controls) by more than 2 standard deviations and were well within the ranges established in obligate heterozygotes for homocystinuria.
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