André Tichelli, MD; Michel Henry-Amar, MD; Gérard Socié, MD
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Tichelli A., Henry-Amar M., Gérard Socié ; Late Clonal Complications in Older Patients Receiving Immunosuppressive Therapy for Aplastic Anemia. Ann Intern Med. 1999;131:633-634. doi: 10.7326/0003-4819-131-8-199910190-00030
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Published: Ann Intern Med. 1999;131(8):633-634.
We agree with Kami and colleagues that the incidence of malignant hematologic conditions was lower in patients 60 years of age or older than in patients age 20 to 49 years or patients age 50 to 59 years. However, we think that it is more appropriate to present these results by using a time-dependent method. The probability of developing a malignant hematologic disorder at 10 years was 12% ± 3% in patients age 20 to 49 years, 17% ± 6% in patients age 50 to 59 years, and 5% ± 3% in patients age 60 years or older. Patients 50 to 59 years of age had a significantly higher risk for developing a malignant hematologic condition at 10 years (P < 0.001) than did the younger and older age group. However, this risk was not statistically significantly lower for patients 60 years or older than for patients 20 to 47 years of age. The lower incidence in patients age 60 years or older is therefore due to the shorter observation time in this group.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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