Johan Askling, MD; Per Sørensen, MSc; Anders Ekbom, MD, PhD; Morten Frisch, MD, PhD; Mads Melbye, MD, PhD; Bengt Glimelius, MD, PhD; Henrik Hjalgrim, MD, PhD
Grant Support: By a grant from the Danish Cancer Society (#KB 97 100 07).
Requests for Reprints: Johan Askling, MD, Department of Medical Epidemiology, Karolinska Institute, Box 281, S-171 77 Stockholm, Sweden; e-mail, Johan.Askling@mep.ki.se. For reprint orders in quantities exceeding 100, please contact the Reprints Coordinator; phone, 215-351-2657; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Askling and Ekbom: Department of Medical Epidemiology, Karolinska Institute, Box 281, S-171 77, Stockholm, Sweden.
Mr. Sørensen and Drs. Melbye and Hjalgrim: Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark.
Dr. Frisch: Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD 20852.
Dr. Glimelius: Department of Oncology, Uppsala Academic Hospital, S-751 85 Uppsala, Sweden.
Askling J, Sørensen P, Ekbom A, Frisch M, Melbye M, Glimelius B, et al. Is History of Squamous-Cell Skin Cancer a Marker of Poor Prognosis in Patients with Cancer?. Ann Intern Med. 1999;131:655-659. doi: 10.7326/0003-4819-131-9-199911020-00004
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Published: Ann Intern Med. 1999;131(9):655-659.
Squamous-cell skin cancer (1-6) and basal-cell skin cancer (7, 8), collectively referred to as nonmelanoma skin cancer, are associated with an increased incidence of subsequent cancer, particularly non-Hodgkin lymphoma (1). Nonmelanoma skin cancer is also associated with increased risk for death from cancer (9), but it is unclear whether this increased risk is caused by increased incidence of subsequent cancer, decreased chance of surviving subsequent cancer, or a combination of the two. We hypothesized that previous squamous-cell skin cancer may indicate poor prognosis in persons who receive a subsequent diagnosis of cancer. A recent study from Denmark (10) found evidence to support this theory in patients with non-Hodgkin lymphoma. We used the population-based Swedish Cancer Registry to determine whether history of squamous-cell skin cancer has prognostic significance in patients with non-Hodgkin lymphoma and patients with the four most common types of cancer in Sweden.
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