Jordi Guardiola, MD; Xavier Xiol, MD; Richard Sallie, MD, FRACP; Joan M. Nolla, MD; Daniel Roig-Escofet, MD; Eduardo Jaurrieta, MD; Luis Casais, MD
Guardiola J, Xiol X, Sallie R, Nolla JM, Roig-Escofet D, Jaurrieta E, et al. Influence of the Vitamin D Receptor Gene Polymorphism on Bone Loss in Men after Liver Transplantation. Ann Intern Med. 1999;131:752-755. doi: 10.7326/0003-4819-131-10-199911160-00006
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Published: Ann Intern Med. 1999;131(10):752-755.
Bone loss is a frequent complication after liver transplantation.
To investigate whether vitamin D receptor gene polymorphism influences bone loss in men after liver transplantation.
Prospective cohort study.
55 male candidates for liver transplantation.
Lumbar spine bone mineral density was measured before and 3, 6, 12, and 24 months after liver transplantation. Vitamin D receptor genotype was determined by restriction endonuclease BsmI.
Vitamin D receptor genotypes were significantly associated with post-transplantation changes in bone mineral density (PÂ =Â 0.028). Within 3 months after transplantation, patients with the genotypes Bb or BB showed a vertebral bone loss substantially greater than that in patients with the bb genotype (between-group difference in the percentage change with respect to baseline bone mineral density, 3.7% [95% CI, 0.6% to 6.9%]). In 3 to 24 months after transplantation, bone mineral density increased steadily in the three allelic groups.
Vitamin D receptor gene polymorphism influences bone loss after liver transplantation. Patients with the bb genotype are, to some extent, protected against post-transplantation bone loss.
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Endocrine and Metabolism, Gastroenterology/Hepatology, Metabolic Bone Disorders, Liver Transplantation, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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