Tim R. Ringrose; Paddy A. Phillips; George B.M. Lindop
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Ringrose T., Phillips P., Lindop G.; Renin-Secreting Adenocarcinoma of the Colon. Ann Intern Med. 1999;131:794-795. doi: 10.7326/0003-4819-131-10-199911160-00029
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Published: Ann Intern Med. 1999;131(10):794-795.
TO THE EDITOR:
We describe what we believe to be the first case of a renin-secreting adenocarcinoma of the colon. A 66-year-old retired schoolteacher presented with a 3-month history of headaches, vomiting, constipation, and weight loss. She had severe hypertension (blood pressure, 210/140 mm Hg) and hypokalemia (potassium level, 2.2 mmol/L). A barium enema showed appearances of cecal carcinoma. Both plasma renin levels (21 pmol/L; normal, 1.1 to 2.7 pmol/L) and plasma aldosterone levels (1010 pmol/L; normal, 100 to 450 pmol/L) were elevated. Potassium supplements and oral spironolactone (100 mg daily) rapidly corrected the hypokalemia, and a calcium antagonist (amlodipine, 10 mg daily) was used to control blood pressure. Abdominal computed tomography showed no renal tumor but demonstrated multiple lesions throughout the liver that were compatible with metastases.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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