Xavier Puéchal, MD; Radwan Saad, MD; Jean-Dominique Poveda, MD
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Puéchal X, Saad R, Poveda J. Tropheryma whippelii in Synovial Tissue and Fluid. Ann Intern Med. 1999;131:795-796. doi: 10.7326/0003-4819-131-10-199911160-00031
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Published: Ann Intern Med. 1999;131(10):795-796.
TO THE EDITOR:
Whipple disease is a systemic infection in which 67% of patients present with articular symptoms (1). These symptoms usually precede diagnosis by a mean of 6 years (range, 6 months to 28 years) (1). The 16S ribosomal RNA (rRNA) of the causal agent of Whipple disease, Tropheryma whippelii, has recently been identified (2). Because of this, 16S rDNA primers are now used to detect this organism by polymerase chain reaction (PCR), mainly in duodenal and lymph node tissues (2-4). We have extended this approach to the diagnosis of Whipple arthritis.
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