Andrew R. Zolopa, MD; Robert W. Shafer, MD; Ann Warford, PhD; Jose G. Montoya, MD; Phillip Hsu, BA; David Katzenstein, MD; Thomas C. Merigan, MD; Brad Efron, PhD
Acknowledgments: The authors thank Mitch Katz, MD, of the Department of Public Health, San Francisco, for critical review of the manuscript, and John Sninsky, PhD, of Roche Molecular Systems, Alameda, California, for contributing PCR kits and reagents used in the HIV-1 sequencing reactions.
Requests for Reprints: Andrew R. Zolopa, MD, Division of Infectious Diseases and Geographical Medicine, Stanford University School of Medicine, Grant Building, Room S-156, Stanford, CA 94305; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Zolopa, Shafer, Warford, Montoya, Hsu, Katzenstein, and Merigan: Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Grant Building Room S-156, Stanford, CA 94305.
Dr. Efron: Department of Statistics, Stanford University, Sequoia Hall, Room 132, Stanford CA 94305.
Zolopa AR, Shafer RW, Warford A, Montoya JG, Hsu P, Katzenstein D, et al. HIV-1 Genotypic Resistance Patterns Predict Response to saquinavir–ritonavir Therapy in Patients in Whom Previous Protease Inhibitor Therapy Had Failed. Ann Intern Med. 1999;131:813-821. doi: 10.7326/0003-4819-131-11-199912070-00003
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Published: Ann Intern Med. 1999;131(11):813-821.
Combination antiretroviral therapy for HIV-1 infection has resulted in profound control of HIV replication in vivo, improved immune function, and significant decreases in AIDS-related morbidity and mortality (1-9). For many persons, however, this therapy does not provide sustained viral suppression or durable clinical benefit (10, 11). Potential reasons for the loss of viral suppression include host immune defects, poor adherence to therapy, pharmacologic factors, and drug resistance (10-17). However, HIV-1 resistance to drug therapy is probably the central factor in the loss of viral suppression (18-22).
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Infectious Disease, HIV.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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