Olivier Mimoz, MD, PhD; Amal Karim, PharmD; Alain Mercat, MD; Marie Cosseron, MD; Bruno Falissard, MD, PhD; Fabrice Parker, MD, PhD; Christian Richard, MD; Kamran Samii, MD; Patrice Nordmann, MD, PhD
Mimoz O, Karim A, Mercat A, Cosseron M, Falissard B, Parker F, et al. Chlorhexidine Compared with Povidone-Iodine as Skin Preparation before Blood Culture: A Randomized, Controlled Trial. Ann Intern Med. 1999;131:834-837. doi: 10.7326/0003-4819-131-11-199912070-00006
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Published: Ann Intern Med. 1999;131(11):834-837.
Chlorhexidine is better than povidone-iodine for care of catheter sites, but it is not known whether chlorhexidine is superior in reducing blood culture contamination.
To determine whether alcoholic chlorhexidine is a more effective skin antiseptic for collection of blood cultures than aqueous povidone-iodine.
Randomized, controlled trial.
Three adult intensive care units in a French university hospital.
403 adults who had at least one blood culture drawn through a peripheral vein.
Patients were randomly assigned to receive skin preparation with an aqueous solution of 10% povidone-iodine or an alcoholic solution of 0.5% chlorhexidine before phlebotomy.
Contamination rates of blood cultures.
Of 2041 blood cultures collected in 403 patients, 124 yielded pathogens. Chlorhexidine reduced the incidence of blood culture contamination more than povidone-iodine (14 of 1019 cultures [1.4%] compared with 34 of 1022 cultures [3.3%]; odds ratio, 0.40 [95% CI, 0.21 to 0.75]; PÂ =Â 0.004).
Skin preparation with alcoholic chlorhexidine is more efficacious than skin preparation with aqueous povidone-iodine in reducing contamination of blood cultures.
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Hospital Medicine, Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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