Neil B. Hampson, MD
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Hampson N.; Inhaled Corticosteroids or Antileukotrienes for Asthma?. Ann Intern Med. 1999;131:865. doi: 10.7326/0003-4819-131-11-199912070-00013
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Published: Ann Intern Med. 1999;131(11):865.
TO THE EDITOR:
The editorial (1) that accompanied the report by Malmstrom and coworkers (2) states that “the antileukotrienes are a good first choice” for patients with mild persistent asthma. The results of the clinical trial seem to suggest otherwise.
In Malmstrom and colleagues' study, patients with chronic asthma were randomly assigned to receive montelukast, inhaled beclomethasone, or placebo (2). When one compares the results in patients receiving one of the active treatments, it is apparent that beclomethasone therapy resulted in 77% greater improvement in FEV1 than montelukast, 64% greater improvement in morning peak expiratory flow rates, 51% greater improvement in daytime asthma symptoms, 40% less β-agonist use, and 54% fewer asthma attacks. There were also 41% fewer nocturnal awakenings per month among beclomethasone-treated patients.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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