Jameela Al-Salman, MD; Heider Arjomand, MD; David G. Kemp, MD; Manoj Mittal, MD
Al-Salman J, Arjomand H, Kemp DG, Mittal M. Hepatocellular Injury in a Patient Receiving Rosiglitazone: A Case Report. Ann Intern Med. 2000;132:121-124. doi: 10.7326/0003-4819-132-2-200001180-00006
Download citation file:
Published: Ann Intern Med. 2000;132(2):121-124.
Rosiglitazone maleate (Avandia, SmithKline Beecham, Philadelphia, Pennsylvania) is a new oral hypoglycemic agent approved for the treatment of type 2 diabetes. It acts primarily by increasing insulin sensitivity. In controlled trials, there has been no evidence of rosiglitazone-induced hepatocellular injury.
To report a case of hepatocellular injury in a patient receiving rosiglitazone.
Community teaching hospital.
61-year-old man receiving rosiglitazone, 4 mg/d for 2 weeks.
Discontinuation of rosiglitazone therapy.
Clinical evaluation and assessment of liver function test results were done daily during hospitalization and periodically after discharge. The outpatient record was also reviewed.
After receiving rosiglitazone for 2 weeks, the patient presented with anorexia, vomiting, and abdominal pain. Liver function tests revealed severe hepatocellular injury. Discontinuation of rosiglitazone therapy led to rapid improvement of liver function and resolution of symptoms.
Rosiglitazone may be associated with hepatocellular injury. We believe that patients receiving rosiglitazone should have liver enzyme levels monitored earlier and more frequently than initially recommended.
Learn more about subscription options.
Register Now for a free account.
Gastroenterology/Hepatology, Liver Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only