Bruce R. Bacon, MD; Robert S. Britton, PhD; John K. Olynyk, MD
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Bacon B., Britton R., Olynyk J.; HFE Genotype in Patients with Hemochromatosis and Other Liver Diseases. Ann Intern Med. 2000;132:246. doi: 10.7326/0003-4819-132-3-200002010-00019
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Published: Ann Intern Med. 2000;132(3):246.
We thank Dr. McLaren for his thoughtful comments about our paper, which clearly described the value of HFE genotyping in patients with liver disease and possible iron overload. We agree with Dr. McLaren that the accompanying editorial by Franks and Burke (1) did not address the issue that we had described—that is, how to differentiate patients with hemochromatosis from those with liver disease and secondary iron overload or those with liver disease and abnormal serum iron measures. We believe our data clearly show the utility of HFE genetic testing in all patients with liver disease who have abnormal iron metabolism measures in order to characterize whether they have HFE mutations that are associated with hemochromatosis. Again, we agree with McLaren that our proposed algorithm should be tested in a larger series of patients, and we have made no comments about the utility of this algorithm in population-based screening. We hope the readers of our article will understand the significance of our findings in terms of evaluating patients with liver disease, a point that obviously was missed in the accompanying editorial.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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