Kristine E. Ensrud, MD, MPH; Tu Duong, MA; Jane A. Cauley, DrPH; Robert P. Heaney, MD; Randi L. Wolf, PhD; Emily Harris, PhD; Steven R. Cummings, MD; Study of Osteoporotic Fractures Research Group*
Acknowledgments: The authors thank Ms. Paula Bowman for her help with preparation of the manuscript.
Grant Support: By the National Institutes of Health and by grants from the Public Health Service (AG05407, AR35582, AG05394, AR35584, and AR35583).
Requests for Single Reprints: Kristine E. Ensrud, MD, MPH, General Internal Medicine (111-0), Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417; e-mail, email@example.com.
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Current Author Addresses: Dr. Ensrud: General Internal Medicine (111-0), Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417.
Ms. Duong and Dr. Cummings: University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105.
Drs. Cauley and Wolf: University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261.
Dr. Heaney: Creighton University, 2500 California Plaza, Omaha, NE 68178.
Dr. Harris: Kaiser Permanente Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227.
Author Contributions: Conception and design: K.E. Ensrud, J.A. Cauley, S.R. Cummings.
Analysis and interpretation of the data: K.E. Ensrud, T. Duong, J.A. Cauley, R.L. Wolf, S.R. Cummings.
Drafting of the article: K.E. Ensrud, J.A. Cauley.
Critical revision of the article for important intellectual content: K.E. Ensrud, J.A. Cauley, R.L. Wolf, S.R. Cummings.
Final approval of the article: K.E. Ensrud, T. Duong, J.A. Cauley, R.P. Heaney, R.L. Wolf, E.L. Harris, S.R. Cummings.
Provision of study materials or patients: K.E. Ensrud, E.L. Harris.
Statistical expertise: T. Duong.
Obtaining of funding: K.E. Ensrud, S.R. Cummings.
Administrative, technical, or logistic support: K.E. Ensrud, R.P. Heaney.
Collection and assembly of data: K.E. Ensrud, T. Duong, R.P. Heaney, E.L. Harris.
Ensrud K., Duong T., Cauley J., Heaney R., Wolf R., Harris E., Cummings S., ; Low Fractional Calcium Absorption Increases the Risk for Hip Fracture in Women with Low Calcium Intake. Ann Intern Med. 2000;132:345-353. doi: 10.7326/0003-4819-132-5-200003070-00003
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Published: Ann Intern Med. 2000;132(5):345-353.
The fraction of calcium absorbed from the gut (fractional calcium absorption) varies widely from person to person, ranging from 10% to 70% (1-3). Cross-sectional studies in postmenopausal women have suggested that fractional calcium absorption increases with decreasing dietary calcium intake and decreases with advancing age (1, 4). It has been hypothesized that decreased ability to absorb calcium with age limits adaptation to low calcium intake and leads to secondary hyperparathyroidism, greater bone resorption, and increased risk for fracture (5, 6). However, to our knowledge, the association between fractional calcium absorption and subsequent risk for fracture has never been studied.
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Endocrine and Metabolism, Geriatric Medicine, Metabolic Bone Disorders.
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