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Poullis M. Serum Uric Acid and Cardiovascular Disease Risk. Ann Intern Med. 2000;132:591-592. doi: 10.7326/0003-4819-132-7-200004040-00015
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Published: Ann Intern Med. 2000;132(7):591-592.
TO THE EDITOR:
The latest report from the Framingham Heart Study disputes the importance of serum uric acid with respect to cardiovascular disease (1).
Diabetes, impaired renal function, and diuretics increase the serum uric acid level. These factors have confounded studies that reported an association between serum uric acid level and left ventricular function and cardiovascular morbidity and mortality.
My colleagues and I analyzed 2729 patients undergoing cardiopulmonary bypass surgery. Patients who were diabetic, had a glomerular filtration rate less than 40 mL/min, or were receiving diuretics were excluded (n = 1567).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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