Bruce F. Culleton, MD; Martin G. Larson, ScD; Daniel Levy, MD
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
Culleton B., Larson M., Levy D.; Serum Uric Acid and Cardiovascular Disease Risk. Ann Intern Med. 2000;132:592. doi: 10.7326/0003-4819-132-7-200004040-00016
Download citation file:
Published: Ann Intern Med. 2000;132(7):592.
First, we thank Drs. Vaccarino and Krumholz for their flattering editorial about our article, particularly their praise of the contributions of the Framingham Heart Study to cardiovascular disease risk assessment (1). We are also pleased to respond to Dr. Alderman's comments.
We believe that critical differences in the designs of the studies may explain their disparate results. First, our report used data collected from a community-based sample. In contrast, Alderman and colleagues' study (2) was clinic-based and included only hypertensive patients. Second, residual confounding may also account for some of the differences. The NHANES I epidemiologic follow-up study (3) seems to have accounted for diabetes by excluding diabetic patients from the longitudinal analyses, but diabetes was identified solely by self-report. This may be important because up to 50% of persons with type 2 diabetes are unaware of their disease. In addition to inadequate adjustment for diabetes, the Chicago Heart Association study also failed to account for diuretic use (4).
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only