Makoto Suzuki, MD; Mareomi Hamada, MD; Kunio Hiwada, MD
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Suzuki M, Hamada M, Hiwada K. Apoptosis in Cardiac Myxoma. Ann Intern Med. 2000;132:681. doi: 10.7326/0003-4819-132-8-200004180-00028
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Published: Ann Intern Med. 2000;132(8):681.
TO THE EDITOR:
Myxoma is well known as a cause of cardiac embolization (1, 2). However, the reason that embolic events frequently occur in patients with cardiac myxoma remains unknown. We report on myxoma cells that were strongly stained by the terminal deoxyribonucleotidyl transferase-mediated dUTP(deoxy uridine 5′-triphosphate)-biotin nick-end labeling (TUNEL) method.
A 78-year-old woman was admitted to our hospital because of a right cardiac tumor. She had recently experienced pulmonary embolism and full-body edema. After a 5.5 × 2.8-cm solid mass with lobulated surface was resected from the right atrial septum and was histopathologically diagnosed as cardiac myxoma, TUNEL was performed in paraformaldehyde-fixed, deparaffinzed 5-µm-thick myxoma tissue using the Apop Tag kit (Oncor, Gaithersburg, Maryland). Myxoma cells were positively stained by TUNEL, indicating apoptosis (Figure).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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