Hervé Zylberberg, MD; M. L. Chaix, MD; Christian Bréchot, MD, PhD
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Zylberberg H., Chaix M., Bréchot C.; Infection with Hepatitis C Virus Genotype 4 Is Associated with a Poor Response to Interferon-α. Ann Intern Med. 2000;132:845-846. doi: 10.7326/0003-4819-132-10-200005160-00029
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Published: Ann Intern Med. 2000;132(10):845-846.
TO THE EDITOR:
The hepatitis C virus (HCV) genotype is a crucial predictive factor of response to interferon-α and is associated with the route of infection (1, 2). Although HCV genotype 4 is generally assumed to be resistant to interferon-α therapy, detailed studies on this issue are still lacking (3, 4).
We studied 74 (5%) patients infected with HCV genotype 4 out of the 1520 HCV-infected patients in our files who had undergone genotyping. Genotype and quantitative viremia were assessed by the Inno-Lipa (Innogenetics, Zwijnaarde, Belgium) and Monitor (Hoffman-LaRoche, Meylan, France) assays, respectively.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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