Anthony E.T. Yeo, MD, MPH, PhD; Akihiro Matsumoto, MD, PhD; Michie Hisada, MD, ScD; James W. Shih, PhD; Harvey J. Alter, MD; James J. Goedert, MD; for the Multicenter Hemophilia Cohort Study*
Acknowledgments: The authors thank Dr. Frances Yellin (Computer Science Corp.) for computer programming and Virginia Lamprecht and Dr. Barbara Kroner (Research Triangle Institute) for study management. They especially thank the study participants, the hemophilia center staff, and the collaborators of the Multicenter Hemophilia Cohort Study for their tireless contributions.
Contract Support: In part by National Cancer Institute contract N01-CP-33002 with Research Triangle Institute.
Requests for Single Reprints: James J. Goedert, MD, Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Room 8012 MSC 7248, Rockville, MD 20852; e-mail, firstname.lastname@example.org.
Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, email@example.com.
Current Author Addresses: Drs. Yeo, Shih, and Alter: National Institutes of Health, Warren Grant Magnuson Clinical Center, Department of Transfusion Medicine, Room 1C711, MSC 1184, Bethesda, MD 20892.
Dr. Matsumoto: Second Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano-ken 390-8621, Japan.
Drs. Hisada and Goedert: Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Room 8012 MSC 7248, Rockville, MD 20852.
Author Contributions: Conception and design: J.W. Shih, H.J. Alter, J.J. Goedert.
Analysis and interpretation of the data: A.E.T. Yeo, M. Hisada, H.J. Alter, J.J. Goedert.
Drafting of the article: A.E.T. Yeo, H.J. Alter, J.J. Goedert.
Critical revision of the article for important intellectual content: A.E.T. Yeo, A. Matsumoto, H.J. Alter.
Final approval of the article: M. Hisada, H.J. Alter, J.J. Goedert.
Statistical expertise: A.E.T. Yeo, M. Hisada, J.J. Goedert.
Obtaining of funding: J.J. Goedert.
Administrative, technical, or logistic support: J.W. Shih, J.J. Goedert.
Collection and assembly of data: A. Matsumoto, M. Hisada, J.J. Goedert.
Infection with hepatitis G virus (HGV), also known as GB virus C, is prevalent but is not known to be associated with any chronic disease. Infection with HGV may affect the risk for AIDS in HIV-infected persons.
To compare AIDS-free survival in patients with and those without HGV infection during 16 years of follow-up after HIV seroconversion.
Subanalysis of a prospective cohort study.
Comprehensive hemophilia treatment centers in the United States and Europe.
131 patients with hemophilia who became HIV-positive between 1978 and 1985.
Age, CCR5 genotype, HIV and HCV viral loads, CD4+ and CD8+ lymphocyte counts, and 12-year AIDS-free survival by HGV positivity (viremia [RNA] or anti-E2 antibodies).
Compared with HGV-negative patients, the 60 HGV-positive patients (46%), including 22 who were positive for HGV RNA, had higher CD4+ lymphocyte counts (difference, 211 cells/mm3 [95% CI, 88 to 333 cells/mm3]) and 12-year AIDS-free survival rates (68% compared with 40%; rate difference, 1.9 per 100 person-years [CI, −0.3 to 4.2 per 100 person-years]), despite similar ages and HIV viral loads. In multivariate proportional hazards models, risk for AIDS was 40% lower for HGV-positive patients independent of age, HIV and HCV viral loads, CD4+ and CD8+ lymphocyte counts, and CCR5 genotype.
Patients with past or current HGV infection have higher CD4+ lymphocyte counts and better AIDS-free survival rates. The mechanism of this association is unknown.
*For a list of collaborators in the Multicenter Hemophilia Cohort Study, see the Appendix.
Product-limit AIDS-free survival (Kaplan–Meier method) measured from estimated dates of HIV seroconversion for 131 patients in the Multicenter Hemophilia Cohort Study.HGVP
Table. Multivariate Proportional Hazards Models of the Effect of Hepatitis G Virus Infection on the Risk for AIDS
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Yeo AE, Matsumoto A, Hisada M, Shih JW, Alter HJ, Goedert JJ, et al. Effect of Hepatitis G Virus Infection on Progression of HIV Infection in Patients with Hemophilia. Ann Intern Med. 2000;132:959-963. doi: 10.7326/0003-4819-132-12-200006200-00006
Download citation file:
Published: Ann Intern Med. 2000;132(12):959-963.
Coagulopathies, Gastroenterology/Hepatology, Hematology/Oncology, HIV, Infectious Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only