Pernille Ravn, MD; Richard D. Wasnich, MD; Giovanni Cizza, MD, PhD
Ravn P., Wasnich R., Cizza G.; Long-Term Prevention of Bone Loss. Ann Intern Med. 2000;133:72-73. doi: 10.7326/0003-4819-133-1-200007040-00015
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Published: Ann Intern Med. 2000;133(1):72-73.
Dr. Lesser hypothesizes that calcium or vitamin D deficiency might have biased our main study finding that alendronate prevents bone loss over 4 years (1). We elected to assess dietary calcium intake and offer nutritional advice rather than provide calcium and vitamin D supplementation. We believed that this naturalistic approach was more appropriate because the prevalence of calcium and vitamin D deficiency is likely to be low in healthy postmenopausal women. We also considered the issue of whether calcium supplementation can prevent bone loss in younger postmenopausal women to be controversial (2). The controversy did, however, prompt us to analyze the effects of calcium intake on bone loss in the placebo group (3).
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