Karen L. Margolis, MD, MPH; Kristine E. Ensrud, MD, MPH; Pamela J. Schreiner, PhD; Holly K. Tabor, PhD; Study of Osteoporotic Fractures Research Group*
Margolis KL, Ensrud KE, Schreiner PJ, Tabor HK, Study of Osteoporotic Fractures Research Group*. Body Size and Risk for Clinical Fractures in Older Women. Ann Intern Med. 2000;133:123-127. doi: 10.7326/0003-4819-133-2-200007180-00011
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Published: Ann Intern Med. 2000;133(2):123-127.
Small body size predicts hip fractures in older women.
To test the hypothesis that small body size predicts the risk for other clinical fractures.
Prospective cohort study.
Population-based listings in four areas of the United States.
8059 ambulatory nonblack women 65 years of age or older.
Weight, weight change since 25 years of age, body mass index, lean body mass and percent body fat, and nonspine fractures during 6.4 years of follow-up.
Compared with women in the highest quartile of weight, women in the lowest quartile had relative risks of 2.0 (95% CI, 1.5 to 2.8) for hip fractures, 2.3 (CI, 1.1 to 4.7) for pelvis fractures, and 2.4 (CI, 1.5 to 3.9) for rib fractures. Adjustment for total-hip bone mineral density eliminated the elevated risk. Results were similar for other body size measures. Smaller body size was not a risk factor for humerus, elbow, wrist, ankle, or foot fractures.
Total body weight is useful in the prediction of hip, pelvis, and rib fractures when bone mineral density has not been measured.
*For investigators in the Study of Osteoporotic Fractures Research Group, see Appendix.
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Endocrine and Metabolism, Geriatric Medicine, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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