Steven Grinspoon, MD; Elizabeth Thomas, NP; Sarah Pitts, BA; Erin Gross, BA; Diane Mickley, MD; Karen Miller, MD; David Herzog, MD; Anne Klibanski, MD
Grinspoon S, Thomas E, Pitts S, Gross E, Mickley D, Miller K, et al. Prevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa. Ann Intern Med. 2000;133:790-794. doi: 10.7326/0003-4819-133-10-200011210-00011
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Published: Ann Intern Med. 2000;133(10):790-794.
Anorexia nervosa is highly prevalent among young women.
To determine prevalence and predictive factors for regional bone loss.
Prospective cohort analysis.
130 women with anorexia nervosa.
Dual-energy x-ray absorptiometry.
The prevalence of osteopenia (−1.0 SD ≥ T-score > −2.5 SD) and osteoporosis (T-score ≤ −2.5 SD) was 50% and 13% for the anterior–posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site.
Bone mineral density is reduced at several skeletal sites in most women with anorexia nervosa. Weight, but not estrogen use, is a significant predictor of BMD in this population at all skeletal sites.
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Endocrine and Metabolism, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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