Seiko Okada, MD; Shinji Teramoto, MD; Rokuro Matsuoka, MD
Okada S., Teramoto S., Matsuoka R.; Recovery from Theophylline Toxicity by Continuous Hemodialysis with Filtration. Ann Intern Med. 2000;133:922. doi: 10.7326/0003-4819-133-11-200012050-00024
Download citation file:
Published: Ann Intern Med. 2000;133(11):922.
TO THE EDITOR:
We describe an 83-year-old woman with chronic obstructive pulmonary disease (COPD) who was brought to our attention because of grand mal convulsion and deep unconsciousness.
She presented with continual seizing and atrial fibrillation marked by a heart rate of 190 beats/min and hypotension. Computed tomography showed no lesion in the brain that would be responsible for refractory seizures. The plasma potassium level was 2.3 mmol/L, and the glucose level was 15.26 mmol/L (275 mg/dL). The serum theophylline level was 793 µmol/L.
Charcoal hemoperfusion was initiated. After 3 hours of hemoperfusion, the theophylline level remained at 538 µmol/L. Anuria with myoglobinuria developed with elevation of the serum creatine kinase level. We then performed continuous hemodialysis with filtration instead of another column of hemoperfusion. Continuous hemodialysis with filtration was successfully discontinued after 72 hours (Figure). The patient slowly achieved full neurologic recovery.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only