Howard S. Friedman, MD
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Friedman H.; Serum Homocysteine and Stroke in Atrial Fibrillation. Ann Intern Med. 2001;134:253-254. doi: 10.7326/0003-4819-134-3-200102060-00027
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Published: Ann Intern Med. 2001;134(3):253-254.
TO THE EDITOR:
Atrial fibrillation (AF) increases the risk for stroke (1). Although warfarin substantially decreases this risk (2), the need for frequent blood sampling to ensure efficacy and to monitor inherent risks of treatment, especially in elderly persons (3), are serious limitations. Cohort studies of AF have defined clinical subgroups with differing risks for stroke (2). However, no chemical predictor of stroke in AF has previously been reported. Elevated serum and plasma homocysteine concentrations have been identified as a risk factor for atherothrombotic diseases in general (4) and for stroke in particular (5). It would therefore be of interest to know the relation of homocysteine levels to stroke in patients with AF.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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