Paolo Fabris, MD; Maurizio Dalla Palma, MD; Fausto de Lalla
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Fabris P., Palma M., de Lalla F.; Idiosyncratic Acute Hepatitis Caused by Paracetamol in Two Patients with Melanoma Treated with High-Dose Interferon-α. Ann Intern Med. 2001;134:345. doi: 10.7326/0003-4819-134-4-200102200-00028
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Published: Ann Intern Med. 2001;134(4):345.
TO THE EDITOR:
Acute hepatitis related to paracetamol dose is well documented, whereas idiosyncratic acute liver injury is almost unknown (1-4).
A 47-year-old man and a 64-year-old woman with cutaneous melanoma began receiving adjuvant therapy with interferon-α2b (Intron-A, Schering-Plough, Italy), 20 MU/m2 daily five times per week during the first month, followed by 20 MU/m2 three times per week for 11 months. An influenza-like syndrome related to interferon-α was treated with paracetamol (500 to 1500 mg/d). After 2 months (for the male patient) and 3 weeks (for the female patient), liver aminotransferase levels progressively increased. Treatment was suspended and the patients were hospitalized for further investigation.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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