Nicholas A. Tritos, MD, DSc; Keith Stuart, MD; Pamela I. Hartzband, MD
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Tritos N., Stuart K., Hartzband P.; Hypothyroidism in Two Patients after Hepatic Arterial Chemoembolization. Ann Intern Med. 2001;134:535. doi: 10.7326/0003-4819-134-6-200103200-00031
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Published: Ann Intern Med. 2001;134(6):535.
TO THE EDITOR:
We describe two patients who had not previously received thyroid therapy and became hypothyroid after arterial chemoembolization.
A 66-year-old woman with metastatic carcinoid and a serum thyroid-stimulating hormone (TSH) level of 3.0 mIU/L (normal, 0.3 to 5.0 mIU/L) underwent hepatic arterial chemoembolization twice within 3 months. She developed clinical hypothyroidism 4 months after the first chemoembolization. Her serum TSH level was greater than 100 mIU/L, her serum thyroxine level was less than 19.3 nmol/L (normal, 64.4 to 154.5 nmol/L), and serum antimicrosomal antibodies were undetectable. A 58-year-old woman with metastatic adenocarcinoma and a serum TSH level of 4.0 mIU/L developed clinical hypothyroidism 2 months after chemoembolization. Her serum TSH level was 18 mIU/L, her serum thyroxine level was 52.8 nmol/L, her free thyroxine index was 0.9 (normal, 1.4 to 3.7), and no serum antiperoxidase antibodies were detectable.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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