Nicholas J. Lekas, MD
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Lekas NJ. Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis. Ann Intern Med. 2001;134:1010. doi: 10.7326/0003-4819-134-10-200105150-00020
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Published: Ann Intern Med. 2001;134(10):1010.
Stevens DL, Kaplan EL, eds. 449 pages. New York: Oxford Univ Pr; 2000. $98.50. ISBN 0195099214. Order phone 800-451-7556.
Field of medicine: Infectious diseases, public health, microbiology, and epidemiology.
Format: Hardcover book.
Audience: Physicians in adult and pediatric infectious disease, public health officials, epidemiologists, and microbiologists.
Purpose: To review the spectrum of clinical problems caused by streptococci and to define current understanding of the epidemiology, physiology, and pathophysiology of these microorganisms.
Content: The book concentrates on the major clinically significant and pathogenic streptococci. Pathophysiologic concepts are reviewed from a molecular perspective. Forty percent of the book is devoted to group A streptococci, focusing on genetic and virulence factors and on the clinical features and pathogenesis of suppurative and nonsuppurative manifestations of infection. Chapters on groups B, C, and G and nonhemolytic streptococci highlight new understanding of the mechanisms of the diverse infections caused by these important pathogens. Enterococcal and pneumococcal infections are reviewed in the context of increasing antimicrobial resistance. Oral streptococci and the pathogenesis of local and extraoral disease caused by these organisms is discussed. Prevention of streptococcal infections with antibiotics and vaccines is addressed comprehensively, and current research in the development of group A and B streptococcal vaccines is reviewed. The many challenges that remain in the prevention of pneumococcal disease are discussed.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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