Francisco Fuentes, MD, PhD; José López-Miranda, MD, PhD; Elias Sánchez, MD, PhD; Francisco Sánchez, MD, PhD; José Paez, MD; Elier Paz-Rojas, BSc; Carmen Marín, PhD; Purificación Gómez, BSc; José Jimenez-Perepérez, MD, PhD; José M. Ordovás, MD, PhD; Francisco Pérez-Jiménez, MD, PhD
The regulatory function of the endothelium is altered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a central role in the development of atherosclerosis.
To determine whether endothelial function in hypercholesterolemic patients is affected by replacing a saturated fatâ€“enriched diet with a low-fat, lowâ€“saturated fat diet (the U.S. National Cholesterol Education Program stage 1 [NCEP-1] diet) or a diet rich in monounsaturated fat (such as that common in Mediterranean countries).
Intervention dietary study with a baseline phase and two randomized crossover dietary periods.
Hospital Universitario Reina SofÃa, CÃ³rdoba, Spain.
22 hypercholesterolemic men.
Patients followed a diet high in saturated fat, then were assigned in a crossover design to the NCEP-1 diet or a Mediterranean diet. Each dietary period lasted 28 days.
Plasma P-selectin levels, lipid concentrations, and endothelial function.
Compared with the saturated fat diet, flow-mediated dilatation increased during the Mediterranean diet but not during the NCEP-1 diet. In addition, levels of plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and P-selectin decreased during the NCEP-1 and Mediterranean diets.
In hypercholesterolemic men, diets low in fat (especially saturated fat) and diets rich in monounsaturated fats improve endothelial function.
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Fuentes F, López-Miranda J, Sánchez E, Sánchez F, Paez J, Paz-Rojas E, et al. Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men. Ann Intern Med. 2001;134:1115-1119. doi: 10.7326/0003-4819-134-12-200106190-00011
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Published: Ann Intern Med. 2001;134(12):1115-1119.
Cardiology, Coronary Risk Factors, Dyslipidemia, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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