Mark G. Graham, MD
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Graham MG. Acute Renal Failure Related to High-Dose Celecoxib. Ann Intern Med. 2001;135:69-70. doi: 10.7326/0003-4819-135-1-200107030-00038
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Published: Ann Intern Med. 2001;135(1):69-70.
TO THE EDITOR:
A 57-year-old woman developed acute renal failure on 6 July 2000. She had been prescribed celecoxib, 200 mg/d, 10 months earlier for symptomatic osteoarthritis and had been followed with bimonthly visits thereafter. Her baseline creatinine and blood urea nitrogen (BUN) levels were normal at 88 µmol/L (1.0 mg/dL) and 3.9 mmol/L (11 mg/dL), respectively. In the last half of June 2000, her orthopedist doubled the daily celecoxib dose to 400 mg. Two weeks later, on 6 July 2000, she presented with marked dependent edema and markedly elevated blood pressure (160/110 mm Hg). Creatinine and BUN levels were elevated at 265 µmol/L (3.0 mg/dL) and 15.4 mmol/L (43 mg/dL), respectively. Celecoxib therapy was discontinued on 7 July 2000, and a complete work-up for acute renal failure was begun on 14 July 2000. Results of the work-up were negative, and renal function returned to normal; creatinine and BUN levels decreased to 88 µmol/L (1.0 mg/dL) and 6.8 mmol/L (19 mg/dL), respectively. Edema and hypertension also resolved.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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