Shruti H. Mehta, MPH; Mark S. Sulkowski, MD; David L. Thomas, MD, MPH
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Mehta SH, Sulkowski MS, Thomas DL. Association of Hepatitis C and Diabetes Mellitus. Ann Intern Med. 2001;135:142. doi: 10.7326/0003-4819-135-2-200107170-00018
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Published: Ann Intern Med. 2001;135(2):142.
We agree with Drs. Knobler and Schattner that histologic examination of the liver in HCV-infected persons with and without type 2 diabetes mellitus contributes to our understanding of the relationship between these conditions. Previous studies have demonstrated that community-identified HCV infection is not usually associated with cirrhosis (1). Thus, we would not anticipate finding a high prevalence of cirrhosis among HCV-infected persons identified in a community setting, such as the participants in NHANES III. While this could not be confirmed in our analysis because liver biopsies were not performed in NHANES, the assumption is supported by a study by Knobler and coworkers, which demonstrated an association between HCV infection and type 2 diabetes mellitus in persons in whom cirrhosis was excluded by biopsy ). The biological mechanism of this association remains to be explained.
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