G. Boudewijn C. Vasbinder, MD; Patricia J. Nelemans, MD, PhD; Alfons G.H. Kessels, MD, MSc; Abraham A. Kroon, MD, PhD; Peter W. de Leeuw, MD, PhD; Jos M.A. van Engelshoven, MD, PhD
Grant Support: By the Dutch Health Care Insurance Board (OG 97-003).
Requests for Single Reprints: G. Boudewijn C. Vasbinder, MD, Department of Radiology, Box 5800, University Hospital of Maastricht, NL-6202 AZ Maastricht, the Netherlands; e-mail, email@example.com.
Current Author Addresses: Drs. Vasbinder, Nelemans, Kessels, Kroon, de Leeuw, and van Engelshoven: Department of Radiology, Box 5800, University Hospital of Maastricht, NL-6202 AZ Maastricht, the Netherlands.
Author Contributions: Conception and design: G.B.C. Vasbinder, P.J. Nelemans, P.W. de Leeuw, J.M.A. van Engelshoven.
Analysis and interpretation of the data: G.B.C. Vasbinder, P.J. Nelemans, J.M.A. van Engelshoven.
Drafting of the article: G.B.C. Vasbinder, P.J. Nelemans, A.A. Kroon.
Critical revision of the article for important intellectual content: G.B.C. Vasbinder, P.J. Nelemans, A.G.H. Kessels, A.A. Kroon, P.W. de Leeuw, J.M.A. van Engelshoven.
Final approval of the article: G.B.C. Vasbinder, P.J. Nelemans, A.G.H. Kessels, A.A. Kroon, P.W. de Leeuw, J.M.A. van Engelshoven.
Provision of study materials or patients: G.B.C. Vasbinder.
Statistical expertise: P.J. Nelemans, A.G.H. Kessels.
Obtaining of funding: J.M.A. van Engelshoven.
Collection and assembly of data: G.B.C. Vasbinder, P.J. Nelemans.
Vasbinder G., Nelemans P., Kessels A., Kroon A., de Leeuw P., van Engelshoven J.; Diagnostic Tests for Renal Artery Stenosis in Patients Suspected of Having Renovascular Hypertension: A Meta-Analysis. Ann Intern Med. 2001;135:401-411. doi: 10.7326/0003-4819-135-6-200109180-00009
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Published: Ann Intern Med. 2001;135(6):401-411.
In a general hypertensive population, the prevalence of renovascular disease varies between 1% and 5% (1, 2). In patients who exhibit specific clinical clues that indicate renovascular hypertension, the probability of having the disease increases to 20% to 40% (3). Renovascular hypertension is currently treated with drugs; surgery; or less invasive techniques, such as percutanous transluminal renal angioplasty with or without stent placement. A recent study found no significant difference between treatment with percutanous transluminal renal angioplasty and antihypertensive drug therapy. However, in that study, 44% of patients who received drug therapy still received percutanous transluminal renal angioplasty (4). Because a large proportion of patients are still preferably treated with angioplasty, a valid diagnostic test is needed in the presence of one or more clinical clues (5). Intra-arterial x-ray angiography is considered the gold standard; however, it is invasive and carries small risks for serious complications, such as arterial dissection or adverse contrast reactions.
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Cardiology, Nephrology, Hypertension, Coronary Risk Factors.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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