Marc Boogaerts, MD, PhD; Drew J. Winston, MD; Eric J. Bow, MD; Gary Garber, MD; Annette C. Reboli, MD; Anthony P. Schwarer, MD, FRACP; Nicolas Novitzky, MD, PhD; Angelika Boehme, MD; Elisabeth Chwetzoff, MD; Karel De Beule, RPh; the Itraconazole Neutropenia Study Group*
Grant Support: By Janssen Research Foundation, Beerse, Belgium.
Requests for Single Reprints: Marc Boogaerts, MD, PhD, Department of Hematology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium; e-mail, email@example.com.
Current Author Addresses: Dr. Boogaerts: Department of Hematology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Dr. Winston: Transplantation Biology Program, UCLA School of Medicine, Center for the Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095-1678.
Dr. Bow: Department of Internal Medicine, The University of Manitoba, Health Sciences Centre, 820 Sherbrooke Street, Winnipeg, Manitoba R3A 1R9, Canada.
Dr. Garber: Division of Infectious Disease, Ottawa Hospital-General Campus, University of Ottawa, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Dr. Reboli: Department of Medicine, Robert Wood Johnson Medical School at Camden, Cooper Hospital, Education and Research Building, 401 Haddon Avenue, Room 270, Camden, NJ 08103.
Dr. Schwarer: Bone Marrow Transplant Programme, Alfred Hospital, Commercial Road, Melbourne, Victoria 3181, Australia.
Dr. Novitzky: Department of Haematology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Anzio Road, Observatory, Cape Town 7925, South Africa.
Dr. Boehme: Medical Clinic III, J.W. Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
Dr. Chwetzoff: Bømloveien 16, 4027 Stavanger, Norway.
Dr. De Beule: Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Author Contributions: Conception and design: M. Boogaerts, D.J. Winston, E. Chwetzoff, K. De Beule.
Analysis and interpretation of the data: M. Boogaerts, D.J. Winston, E.J. Bow, G. Garber, A.P. Schwarer, N. Novitzky, K. De Beule.
Drafting of the article: M. Boogaerts, D.J. Winston, E.J. Bow, G. Garber, A.P. Schwarer, N. Novitzky, K. De Beule.
Critical revision of the article for important intellectual content: M. Boogaerts, D.J. Winston, E.J. Bow, G. Garber, A.C. Reboli, A.P. Schwarer, N. Novitzky, A. Boehme.
Final approval of the article: M. Boogaerts, D.J. Winston, E.J. Bow, G. Garber, A.C. Reboli, A.P. Schwarer, N. Novitzky, A. Boehme, E. Chwetzoff, K. De Beule.
Provision of study materials or patients: D.J. Winston, G. Garber, A.C. Reboli, A.P. Schwarer, N. Novitzky, A. Boehme.
Statistical expertise: E.J. Bow.
Collection and assembly of data: D.J. Winston.
Boogaerts M., Winston D., Bow E., Garber G., Reboli A., Schwarer A., Novitzky N., Boehme A., Chwetzoff E., De Beule K., ; Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy: A Randomized, Controlled Trial. Ann Intern Med. 2001;135:412-422. doi: 10.7326/0003-4819-135-6-200109180-00010
Download citation file:
Published: Ann Intern Med. 2001;135(6):412-422.
Prolonged neutropenia is a major risk factor for invasive fungal infection (1-6). The incidence among neutropenic patients with cancer who are receiving intensive cytotoxic therapy ranges from 2% to 47%, depending on other concomitant risk factors (7). Mortality rates range from 35% to 90% (8). Fever may be the only clinical sign of infection, and definitive diagnosis is often problematic. Empirical therapy with amphotericin B deoxycholate reduces the relative risk for documented infection by 50% to 80% and overall mortality rates by 23% to 45% (1, 2, 9, 10). This practice is now standard in neutropenic patients with cancer who have persistent fever that does not respond to 3 to 7 days of treatment with broad-spectrum antibiotics (11).
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only