Yngve Falck-Ytter, MD; Hemangi Kale, MD; Kevin D. Mullen, MD; Steedman A. Sarbah, MD; Lucian Sorescu, MD; Arthur J. McCullough, MD
Falck-Ytter Y, Kale H, Mullen KD, Sarbah SA, Sorescu L, McCullough AJ. Surprisingly Small Effect of Antiviral Treatment in Patients with Hepatitis C. Ann Intern Med. 2002;136:288-292. doi: 10.7326/0003-4819-136-4-200202190-00008
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Published: Ann Intern Med. 2002;136(4):288-292.
The effect and applicability of interferon-based antiviral therapies in the general population of persons with hepatitis C virus (HCV) infection are unknown.
To determine the applicability and usefulness of anti-viral therapy in a metropolitan clinic population.
Retrospective case series of consecutively referred patients.
A teaching county hospital in Cleveland, Ohio.
327 patients referred to a liver clinic after a positive result for antibody against HCV on enzyme-linked immunosorbent assay (ELISA).
Treatment rates; reasons for nontreatment.
34 patients had no detectable HCV RNA. Of the remaining 293 patients, 72% were not treated for the following reasons: 37% did not adhere to evaluation procedures, 34% had medical or psychiatric contraindications, 13% had ongoing substance or alcohol abuse, 11% preferred no treatment, and 5% had normal liver enzyme levels. Only 83 patients (28%) were treated; 13% had a sustained viral response.
Most patients with HCV infection are not candidates for interferon-based therapies; alternative interventions should be sought for these patients.
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Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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