Paul Moayyedi; Jonathan Deeks; David Forman
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Moayyedi P, Deeks J, Forman D. Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia. Ann Intern Med. 2002;136:555. doi: 10.7326/0003-4819-136-7-200204020-00016
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Published: Ann Intern Med. 2002;136(7):555.
TO THE EDITOR:
We were interested to read the systematic review by Laine and colleagues (1) suggesting that Helicobacter pylori eradication therapy was not effective in nonulcer dyspepsia. We previously published a systematic review within the Cochrane Collaboration that reached a different conclusion (2), namely, that H. pylori eradication was associated with an increase in cure of symptoms in nonulcer dyspepsia. The effect size we observed was modest (reduction in dyspepsia rate, 9% [95% CI, 5% to 14%]) but statistically significant (P < 0.001), and an economic analysis suggested that H. pylori eradication may be cost-effective in patients with nonulcer dyspepsia (3). This conclusion was maintained in all sensitivity analyses and did not depend on the results of any one trial.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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