Philip Greenland, MD; Laura Colangelo, MS
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Greenland P., Colangelo L.; Long-Term Prediction of Coronary Heart Disease in Young Men. Ann Intern Med. 2002;136:631-632. doi: 10.7326/0003-4819-136-8-200204160-00017
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Published: Ann Intern Med. 2002;136(8):631-632.
Gami and colleagues correctly note that we measured plasma glucose following a 50-g oral glucose load, as described else-where (1). We also evaluated serum cholesterol, blood pressure, cig-arette smoking, weight, height, electrocardiographic data, education, and ethnicity. The primary goal of our analysis was to determine whether traditional CHD risk factors differed between young and middle-aged men in follow-up for long-term mortality. To answer Gami and colleagues' question concerning asymptomatic glycemia and long-term CHD mortality, we included plasma glucose level (in increments of 1.11 mmol/L [20 mg/dL]) in the multivariate models we originally reported (Table). After adjustment for major covari-ates, plasma glucose level and 20-year CHD mortality had a border-line relationship in middle-aged men (relative risk, 1.03 [95% CI, 1.00 to 1.06]) and were not significantly related in men who were 18 to 39 years of age at baseline. However, no significant difference was seen in CHD risk between the two age groups because of overlap-ping confidence intervals (P > 0.2).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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