Hiroshi Iwata, MD; Tomonori Aoyama, MD; Masahiro Kami, MD
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Iwata H., Aoyama T., Kami M.; Effects of Pravastatin in the Elderly. Ann Intern Med. 2002;136:W2. doi: 10.7326/0003-4819-136-11-200206040-w2
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Published: Ann Intern Med. 2002;136(11):W2.
TO THE EDITOR:
We would like to comment on Hunt and colleagues' subgroup analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) trial (1), especially the risk for cancer associated with long-term use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. A recent meta-analysis demonstrated no association between statin use over a 5-year period and risk for fatal and nonfatal cancer (2). However, this conclusion was limited because the follow-up of the studies analyzed was relatively short and incidence of cancer was not a primary objective. We believe that the true association between long-term use of HMG-CoA reductase inhibitors and risk for cancer merits further investigation.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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