Dmitri Kirpichnikov, MD; Samy I. McFarlane, MD; James R. Sowers, MD
Acknowledgments: The authors thank Jun Ren, PhD; Amy Davidoff, PhD; and Jacob Peuler, PhD, for their seminal contribution to work on the cardiovascular effects of metformin.
Grant Support: By the National Institutes of Health (RO1-HL-63904-01), the Veterans Affairs Merit Review, and the American Diabetic Association.
Requests for Single Reprints: James R. Sowers, MD, State University of New York Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 1205, Brooklyn, NY 11203; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. Kirpichnikov, McFarlane, and Sowers: State University of New York Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 1205, Brooklyn, New York 11203.
Kirpichnikov D., McFarlane S., Sowers J.; Metformin: An Update. Ann Intern Med. 2002;137:25-33. doi: 10.7326/0003-4819-137-1-200207020-00009
Download citation file:
Published: Ann Intern Med. 2002;137(1):25-33.
Insulin resistance contributes greatly to development of cardiovascular disease in patients with the metabolic syndrome and its extreme presentation, type 2 diabetes mellitus. Therefore, treatment with an insulin-sensitizing agent, such as metformin, in patients with type 2 diabetes mellitus may correct several of the primary pathophysiologic abnormalities of the metabolic syndrome. In diabetic patients, metformin appears to provide cardiovascular protection that cannot be attributed only to its antihyperglycemic effects. These additional cardioprotective effects in these patients may be related to the favorable actions of metformin on lipid metabolism, vascular smooth-muscle and cardiomyocyte intracellular calcium handling, endothelial function, hypercoagulation, and platelet hyperactivity. We discuss known mechanisms by which metformin exerts its beneficial glycemic and cardiovascular actions.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only