Laszlo Littmann, MD; Justin D. Anderson, MD; Michael H. Monroe, MD
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Littmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A Hazardous Combination. Ann Intern Med. 2002;137:W1. doi: 10.7326/0003-4819-137-1-200207020-w1
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Published: Ann Intern Med. 2002;137(1):W1.
TO THE EDITOR:
Aggrenox (Boehringer Ingelheim, Ingelheim, Germany), a combination of low-dose aspirin and extended-release dipyridamole, is a new, effective medication for secondary stroke prevention (1). Patients taking Aggrenox may be referred for adenosine nuclear perfusion heart scans or could be considered for termination of supraventricular tachycardia with intravenous adenosine. Because dipyridamole inhibits cellular reuptake and breakdown of adenosine, the extended-release formulation may exaggerate the negative chronotropic and dromotropic effects of injected adenosine. Warning letters were recently published in the cardiology literature about the possible hazard associated with adenosine stress tests in patients taking Aggrenox (2, 3), but to our knowledge the actual occurrence of this type of drug interaction has not yet been reported.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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