David M. Cook, MD
Growth hormone as therapy for adults with growth hormone deficiency has not been universally accepted by endocrinologists who treat adult patients. The following are addressed in this commentary: the evidence on safety and efficacy in the literature supporting the idea that growth hormone should be offered as replacement therapy to adults who are growth hormone deficient; common concerns of the average prescribing endocrinologist, including the purported association between insulin-like growth factor-I and malignant neoplasms and quality-of-life issues with long-term therapy; and controversial subjects, such as differences in dosing for adults versus children and diagnostic issues. This analysis should encourage reluctant practitioners to at least consider growth hormone replacement therapy for patients with definite growth hormone deficiencyâ€”that is, patients with symptomatic panhypopituitarism.
Learn more about subscription options.
Register Now for a free account.
Cook DM. Shouldn't Adults with Growth Hormone Deficiency Be Offered Growth Hormone Replacement Therapy?. Ann Intern Med. 2002;137:197-201. doi: 10.7326/0003-4819-137-3-200208060-00012
Download citation file:
Published: Ann Intern Med. 2002;137(3):197-201.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only