Patrick Y. Lee, MD; David B. Matchar, MD; Dennis A. Clements, MD, PhD; Joel Huber, PhD; John D. Hamilton, MD; Eric D. Peterson, MD, MPH
Acknowledgments: The authors thank the staff of the Triangle Family Practice in Durham, North Carolina, for help with patient surveys. They also thank Patricia Cowper for assistance in obtaining data on U.S. labor wages.
Grant Support: By the National Institutes of Health (NIH Grant T35-GM08679), a grant from the Faculty Challenge Research Program in Health Sector Management, and an Alpha Omega Alpha Student Research Fellowship.
Requests for Single Reprints: Eric D. Peterson, MD, MPH, Duke University Medical Center, Box 3236, Durham, NC 27710; e-mail, firstname.lastname@example.org.
Current Author Addresses: Dr. Lee: Stanford University School of Medicine, Room S101, Department of Medicine, Stanford, CA 94305.
Dr. Matchar: Duke Center for Clinical Health Policy Research, 2200 West Main Street, Durham, NC 27705.
Dr. Clements: Duke University Medical Center, Box 3810, Durham, NC 27710.
Dr. Huber: Fuqua School of Business, Duke University, Box 90120, Durham, NC 27708.
Dr. Hamilton: Duke University Medical Center, Durham, NC 27710.
Dr. Peterson: Duke University Medical Center, Box 3236, Durham, NC 27710.
Author Contributions: Conception and design: P.Y. Lee, D.B. Matchar, J. Huber, J.D. Hamilton, E.D. Peterson.
Analysis and interpretation of the data: P.Y. Lee, D.B. Matchar, D.A. Clements, J. Huber, E.D. Peterson.
Drafting of the article: P.Y. Lee, E.D. Peterson.
Critical revision of the article for important intellectual content: P.Y. Lee, D.B. Matchar, J. Huber, J.D. Hamilton, E.D. Peterson.
Final approval of the article: P.Y. Lee, D.A. Clements, J.D. Hamilton, E.D. Peterson.
Provision of study materials or patients: P.Y. Lee, D.A. Clements, E.D. Peterson.
Statistical expertise: P.Y. Lee, J. Huber.
Obtaining of funding: P.Y. Lee, E.D. Peterson.
Administrative, technical, or logistic support: P.Y. Lee.
Collection and assembly of data: P.Y. Lee, E.D. Peterson.
Lee P., Matchar D., Clements D., Huber J., Hamilton J., Peterson E.; Economic Analysis of Influenza Vaccination and Antiviral Treatment for Healthy Working Adults. Ann Intern Med. 2002;137:225-231. doi: 10.7326/0003-4819-137-4-200208200-00005
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Published: Ann Intern Med. 2002;137(4):225-231.
Each year, influenza affects 10% to 20% of the U.S. population (1). In high-risk populations, such as elderly persons, influenza causes up to 20 000 deaths per year (2). Even in young healthy persons, influenza significantly affects direct health care costs, losses in worker productivity, and quality of life (3). In terms of therapy, yearly vaccination can reduce the risk for influenza, and various antiviral medications (for example, amantadine, rimantadine, zanamivir, and oseltamivir) can decrease the duration of illness for a person with influenza. However, yearly vaccination of healthy adults is not absolutely recommended, and it remains unclear whether the benefits of anti-influenza medications justify the costs (4, 5).
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Infectious Disease, Vaccines/Immunization, Influenza, Prevention/Screening.
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