Ole Kirk, MD; Peter Reiss, MD; Caterina Uberti-Foppa, MD; Markus Bickel, MD; Jan Gerstoft, MD; Christian Pradier, MD; Ferdinand W. Wit, MD; Bruno Ledergerber, PhD; Jens D. Lundgren, MD; Hansjakob Furrer, MD; for Seven European HIV Cohorts*
Grant Support: The EuroSIDA study was supported by grants from the European Commission BIOMED 1 (CT94-1637) and BIOMED 2 (CT97-2713) programs and the fifth framework program (QLK2-2000-00773); from GlaxoSmithKline, Roche, and Boehringer-Ingelheim; and from the Swiss Federal Office for Education and Science (Swiss sites only). The Swiss HIV Cohort Study was supported by grant 3345-062041 from the Swiss National Science Foundation. The AIDS Therapy Evaluation Project Netherlands was supported by grant CURE/97-46486 from the Health Insurance Fund Council, Amstelveen, the Netherlands. The Frankfurt HIV Cohort was supported by grants from the Bundesministerium für Bildung und Forschung (BMBF 01KI9406/6 and 01KI9718) and GlaxoSmithKline Research.
Requests for Single Reprints: Ole Kirk, MD, Coordinating Centre of EuroSIDA, Department of Infectious Diseases, Hvidovre University Hospital, Kettegaard Alle, 2650 Hvidovre, Denmark; e-mail, email@example.com.
Current Author Addresses: Drs. Kirk and Lundgren: Coordinating Centre of EuroSIDA, Department of Infectious Diseases, Hvidovre University Hospital, Kettegaard Alle, 2650 Hvidovre, Denmark.
Drs. Reiss and Wit: Academic Medical Center, University of Amsterdam, Division of Infectious Diseases, Tropical Medicine, and AIDS, and National AIDS Therapy Evaluation Center, Amsterdam, The Netherlands.
Dr. Uberti-Foppa: San Raffaele Hospital, Infectious Diseases Department, Milan, Italy.
Dr. Bickel: J.W. Goethe University Clinic, Department of Infectious Diseases, Frankfurt, Germany.
Dr. Gerstoft: Rigshospitalet, Department of Infectious Diseases, Copenhagen, Denmark.
Dr. Pradier: Hopital l'Archet, Tropical and Infectious Diseases Department, Nice, France.
Dr. Ledergerber: University Hospital Zürich, Division of Infectious Diseases and Hospital Epidemiology, Zürich, Switzerland.
Dr. Furrer: University Hospital Bern, Division of Infectious Diseases, Bern, Switzerland.
Author Contributions: Conception and design: O. Kirk, P. Reiss, B. Ledergerber, J.D. Lundgren, H. Furrer.
Analysis and interpretation of the data: O. Kirk, B. Ledergerber, J.D. Lundgren, H. Furrer.
Drafting of the article: O. Kirk, B. Ledergerber, J.D. Lundgren, H. Furrer.
Critical revision of the article for important intellectual content: O. Kirk, P. Reiss, J.D. Lundgren, H. Furrer.
Final approval of the article: O. Kirk, P. Reiss, C. Uberti-Foppa, M. Bickel, J. Gerstoft, C. Pradier, F.W. Wit, B. Ledergerber, J.D. Lundgren, H. Furrer.
Provision of study materials or patients: O. Kirk, P. Reiss, C. Uberti-Foppa, M. Bickel, J. Gerstoft, C. Pradier, F.W. Wit, H. Furrer.
Statistical expertise: O. Kirk, B. Ledergerber.
Obtaining of funding: O. Kirk, J.D. Lundgren, H. Furrer.
Administrative, technical, or logistic support: O. Kirk, B. Ledergerber, H. Furrer.
Collection and assembly of data: O. Kirk, C. Uberti-Foppa, M. Bickel, C. Pradier, F.W. Wit, H. Furrer.
Kirk O., Reiss P., Uberti-Foppa C., Bickel M., Gerstoft J., Pradier C., Wit F., Ledergerber B., Lundgren J., Furrer H., ; Safe Interruption of Maintenance Therapy against Previous Infection with Four Common HIV-Associated Opportunistic Pathogens during Potent Antiretroviral Therapy. Ann Intern Med. 2002;137:239-250. doi: 10.7326/0003-4819-137-4-200208200-00008
Download citation file:
Published: Ann Intern Med. 2002;137(4):239-250.
Immune restoration has been demonstrated among HIV-infected patients who respond to potent antiretroviral therapy. Increasing memory and naive CD4 lymphocyte counts and recovery of CD4 lymphocyte reactivity against opportunistic pathogens have been documented (1-3). Resolution of active ongoing opportunistic infections after initiation of antiretroviral therapy has also been reported (4-8). As a result, the question arose whether chemoprophylaxis against opportunistic infections could be interrupted after CD4 lymphocyte counts had increased to levels at which the risk for opportunistic infections is limited (9).
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only