Tazeen H. Jafar, MD, MPH; Christopher H. Schmid, PhD; Andrew S. Levey, MD
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Jafar T., Schmid C., Levey A.; Effect of Angiotensin-Converting Enzyme Inhibitors on Progression of Nondiabetic Renal Disease. Ann Intern Med. 2002;137:298-299. doi: 10.7326/0003-4819-137-4-200208200-00026
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Published: Ann Intern Med. 2002;137(4):298-299.
TO THE EDITOR:
In our article on angiotensin-converting enzyme (ACE) inhibitors and progression of nondiabetic renal disease (1), we stated that regimens containing ACE inhibitors are more effective in slowing the progression of nondiabetic renal disease than regimens that do not include them. Drs. Schrier and Estacio, in their accompanying editorial (2), consider our findings “an exciting hypothesis that warrants confirmation” and state that meta-analysis cannot produce definitive conclusions. Others have concluded, however, that a well-conducted meta-analysis of randomized clinical trials of individual patient data provides the highest level of evidence in support of a therapeutic intervention (3).
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