Anthony B. Miller, MB, FRCP; Teresa To, PhD; Cornelia J. Baines, MD; Claus Wall, MSc
Seven- and 10-year results of the Canadian National Breast Screening Study (CNBSS) showed no reduction in breast cancer mortality from five annual mammographies and breast examinations for 40- to 49-year-old women.
Some authors have argued that longer follow-up would reveal important benefits.
After 11 to 16 years, the cumulative rate ratios for mammography versus usual care were 0.97 (95% CI, 0.74 to 1.27) for breast cancer mortality without adjustment for nonstudy mammography and 1.06 (CI, 0.80 to 1.40) with adjustment.
The CNBSS suggests that screening 40- to 49-year-old women is unlikely to reduce breast cancer by 20% or more.
Controversy will persist because other studies suggest that screening causes small reductions in breast cancer mortality.
Appendix Table 1.
Appendix Table 2.
Appendix Table 3.
Appendix Table 4.
The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.
Miller AB, To T, Baines CJ, Wall C. The Canadian National Breast Screening Study-1: Breast Cancer Mortality after 11 to 16 Years of Follow-up: A Randomized Screening Trial of Mammography in Women Age 40 to 49 Years. Ann Intern Med. 2002;137:305-312. doi: 10.7326/0003-4819-137-5_Part_1-200209030-00005
Download citation file:
Published: Ann Intern Med. 2002;137(5_Part_1):305-312.
Breast Cancer, Hematology/Oncology.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only