Anthony B. Miller, MB, FRCP; Teresa To, PhD; Cornelia J. Baines, MD; Claus Wall, MSc
Miller AB, To T, Baines CJ, Wall C. The Canadian National Breast Screening Study-1: Breast Cancer Mortality after 11 to 16 Years of Follow-up: A Randomized Screening Trial of Mammography in Women Age 40 to 49 Years. Ann Intern Med. 2002;137:305-312. doi: 10.7326/0003-4819-137-5_Part_1-200209030-00005
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Published: Ann Intern Med. 2002;137(5_Part_1):305-312.
Seven- and 10-year results of the Canadian National Breast Screening Study (CNBSS) showed no reduction in breast cancer mortality from five annual mammographies and breast examinations for 40- to 49-year-old women.
Some authors have argued that longer follow-up would reveal important benefits.
After 11 to 16 years, the cumulative rate ratios for mammography versus usual care were 0.97 (95% CI, 0.74 to 1.27) for breast cancer mortality without adjustment for nonstudy mammography and 1.06 (CI, 0.80 to 1.40) with adjustment.
The CNBSS suggests that screening 40- to 49-year-old women is unlikely to reduce breast cancer by 20% or more.
Controversy will persist because other studies suggest that screening causes small reductions in breast cancer mortality.
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