Jean-Benoît Arlet, MD; Bruno Varet, MD; Caroline Besson, MD
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
Arlet J., Varet B., Besson C.; Favorable Long-Term Outcome of a Patient with Transcobalamin II Deficiency. Ann Intern Med. 2002;137:704-705. doi: 10.7326/0003-4819-137-8-200210150-00033
Download citation file:
Published: Ann Intern Med. 2002;137(8):704-705.
TO THE EDITOR:
Background: Transcobalamin II (TCII) deficiency is a rare autosomal recessive disease. Transcobalamin II is a major plasma transport protein for cobalamin. The TCII–cobalamin complex binds to a cell receptor and is then internalized. Therefore, TCII deficiency leads to cellular cobalamin deficiency and results in early-onset megaloblastic anemia, immunologic deficiency, and neurologic abnormalities. Of interest, serum cobalamin levels are normal in patients with TCII deficiency, indicating that most cobalamin is carried by transcobalamin I. Transcobalamin II deficiency is diagnosed if plasma levels of TCII are undetectable. The first case of this disorder was reported 30 years ago. Since then, fewer than 50 pediatric cases have been reported, and favorable outcome in adulthood is rare.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only