William M. Vollmer, PhD; Frank M. Sacks, MD; Lawrence J. Appel, MD
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Vollmer W., Sacks F., Appel L.; Subgroup Results in the DASH-Sodium Trial. Ann Intern Med. 2002;137:772-773. doi: 10.7326/0003-4819-137-9-200211050-00019
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Published: Ann Intern Med. 2002;137(9):772-773.
Drs. Jürgens and Graudal base their argument on the observation that, although reduced sodium significantly lowered systolic blood pressure in nonhypertensive white persons, it did not significantly lower diastolic blood pressure in this subgroup. First, the effect on diastolic blood pressure in this group was indeed significant (−1.4 mm Hg [95% CI, −2.8 mm Hg to −0.1 mm Hg] in those following the control diet). Second, we would like to clarify that our subgroup results for this trial have consistently reported data for African-American persons versus non–African-American persons; the latter group is composed predominantly of white persons. Finally, our Table 4 actually provides estimated effects for nonhypertensive non–African-American persons in each of four age–sex subgroups. All four estimated effects on systolic blood pressure were statistically significant, and three of four effects on diastolic blood pressure had P values less than 0.10. Given that the trial was not powered to look at many subgroups simultaneously, we find these results impressive.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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